Crosslinking of Gelatin-based drug carriers by Genipin induces changes in drug kinetic profiles in vitro

Thakur, Goutam and Mitra, Analava and Rousseau, De´rick and Basak, Amit and Sarkar, Siddik and Pal, Kunal (2010) Crosslinking of Gelatin-based drug carriers by Genipin induces changes in drug kinetic profiles in vitro. Journal of materials science. Materials in medicine, 22 (1). pp. 115-123. ISSN 1573-4838

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Abstract

Hydrogels are extensively studied as carrier matrices for the controlled release of bioactive molecules. The aim of this study was to design gelatin-based hydrogels crosslinked with genipin and study the impact of crosslinking temperature (5, 15 or 25�C) on gel strength, microstructure, cytocompatibility, swelling and drug release. Gels crosslinked at 25�C exhibited the highest Flory–Rehner crosslink density, lowest swelling ratio and the slowest release of indomethacin (Idn, model antiinflammatory drug). Diffusional exponents (n) indicated non-Fickian swelling kinetics while drug transport was anomalous. Hydrogel biocompatibility, in vitro cell viability, cell cycle experiments with AH-927 and HaCaT cell lines indicated normal cell proliferation without any effect on cell cycle. Overall, these results substantiated the use of genipin-crosslinked hydrogels as a viable arrier matrix for drug release applications.

Item Type: Article
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 29 Jul 2011 09:28
Last Modified: 29 Jul 2011 09:28
URI: http://eprints.manipal.edu/id/eprint/1091

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