Alpha-amylase Activity of Tannin Isolated from Terminalia Chebula

Mukherjee, Sutapa and Mitra, Analava and Dey, Satyahari and Thakur, Goutam (2010) Alpha-amylase Activity of Tannin Isolated from Terminalia Chebula. In: Proceedings of 2010 International Conference on Systems in Medicine and Biology, 16-18 December 2010, liT Kharagpur, India.

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Abstract

One important therapeutic approach for the treatment of Type 2 Diabetes Mellitus is by decreasing the postprandial increase of glucose. This is possible by inhibiting certain carbohydrate hydrolyzing enzymes like alpha-amylase. In the present study, the inhibitory effect of tannins isolated from the alcoholic extract of fruits of Terminalia chebula was evaluated for the first time with porcine pancreatic amylase and potato starch as substrate. The result indicated that highest inhibition (52%) was obtained at the concentration of lOOl1g/ml of tannins extracted from the fruits. The result was comparable to that of Acarbose which is a very effective antidiabetic agent.

Item Type: Conference or Workshop Item (Paper)
Uncontrolled Keywords: type 2 diabetes mellitus; postprandial; alpha-amylase enzyme; tannins; acarbose
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 02 Aug 2011 04:15
Last Modified: 02 Aug 2011 04:15
URI: http://eprints.manipal.edu/id/eprint/1101

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