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Comparison of Chitosan - Poly Vinyl Alcohol and Chitosan - Hydroxyapatite Composite Membrane as Wound Healing Material

Thakur, Goutam and Rani, Sheba N D and Chakraborty, S N and Pal, S (2005) Comparison of Chitosan - Poly Vinyl Alcohol and Chitosan - Hydroxyapatite Composite Membrane as Wound Healing Material. In: 12th International conference on Biomedical Engineering , 7-11 December, 2005, Suntec City, Singapore. (Submitted)

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Abstract

Wound healing is a complex process and is promoted by dressings that maintain a moist environment but allow excess fluid to escape without permitting wound desiccation. Chitosan is biodegradable, biocompatible, non-toxic and antithrombogenic, thus allowing it to be a good biomaterial for wound management, space filling implants etc. This study aims at the development of advanced biomaterial having desirable mechanical as well as biological properties for wound management. This includes the development of chitosan-Poly vinyl Alcohol blended membrane and chitosan-Hydroxyapatite composite membrane, characterization and comparison of results, along with in vivo assessment of the membranes for their effectiveness as wound healing material. The membranes were characterized for their strength, swelling properties and effect of sol viscosity on membrane strength and absorption. These membranes did not elicit adverse reactions and were biodegradable. Chitosan-Hydroxyapatite membrane promoted better healing, with faster and orderly reorganization of wounded area into healthy new skin in rats. Clinical trial on paraplegic patients with bedsores, elicited excellent wound healing. Analyses done with various membranes yielded favourable results for the chitosan-Hydroxyapatite membrane as a wound healing material. The features observed in the membrane make it a significant and effective resorbable wound healing material.

Item Type: Conference or Workshop Item (Paper)
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 01 Aug 2011 10:47
Last Modified: 01 Aug 2011 10:47
URI: http://eprints.manipal.edu/id/eprint/1105

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