*, Sonkusare Shipra and Kushtagi, Pralhad (2007) Effect of menopausal hormone replacement therapy on fibrinogen and antithrombin III levels. Journal of Obstetrics Gynecolgy of India , 57 (2). pp. 135-138.

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Abstract

OBJECTIVE(S): To study the effect of hormone replacement therapy (HRT) on fibrinogen (1+2) and antithrombin III levels. METHOD(S): Forty consecutive consenting menopausal (surgical menopause 20 and natural menopause 20) women were recruited for this study. Fibrinogen and antithrombin III levels were determined before, and 3 and 6 months after initiation of HRT. Paired t- test was used to study the alterations with time. RESULTS: Though, the subject characteristics in both groups were similar, the preHRT lipid profile of those with natural menopause had significantly higher triglyceride (159 + 27 vs 138+31; P<0.05) and lower high-density lipoprotein levels (44+7 vs 54+9; P<0.01) than those of the subjects with surgical menopause. Both groups showed significantly increased fibrinogen values at 6 months of HRT use and the rise in levels appeared to increase significantly with duration of use whereas antithrombin III levels showed significantly decreasing trend with the duration of use of HRT. CONCLUSION(S): In the early part of use of HRT, alterations in fibrinogen and antithrombin III levels, towards more thrombogenic state occur.

Item Type:	Article
Uncontrolled Keywords:	menopausal changes, hormone replacement therapy, fibrinogen levels, antithrombin III levels
Subjects:	Medicine > KMC Mangalore > Obstetrics & Gynaecology
Depositing User:	KMCMLR User
Date Deposited:	13 Sep 2011 09:36
Last Modified:	18 Oct 2011 06:36
URI:	http://eprints.manipal.edu/id/eprint/1271

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