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Diuretic activity of NR-ANX-C (a polyherbal formulation) in normal rats

Chatterjee, Dipsankar and Pai, Preethi Ganapathi and Nair, Vinod and Herur , Naranappa Gopalakrishna and Ullal, Sheetal and Pai, Mirabel Rita Sobina Monteiro (2010) Diuretic activity of NR-ANX-C (a polyherbal formulation) in normal rats. Journal of Pharmacy Research, 3 (5). pp. 956-959. ISSN 0974-6943

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Abstract

The present study was undertaken to investigate the diuretic properties of NR-ANX-C, a polyherbal formulation in normal rats. The study was conducted in saline primed wistar albino rats (n=6) using hydrochlorthiazide (10 mg/kg) as the reference diuretic drug. The test drug was evaluated at three different oral doses, 25mg/kg, 50mg/kg and 100mg/kg respectively. Electrolytes (Sodium, Potassium and Chloride) excretion was estimated and the diuretic activity was calculated. Results revealed that the formulation showed significant diuretic activity as evidenced by increase in the urinary output and significant increase in sodium, potassium and chloride ion excretion in the 100mg/kg test group as compared to control group. This study supports the use of NR-ANX-C,a polyherbal formulation as a diuretic agent.

Item Type: Article
Uncontrolled Keywords: Diuretic activity, NR-ANX-C, polyherbal formulation
Subjects: Medicine > KMC Mangalore > Pharmacology
Depositing User: KMCMLR User
Date Deposited: 12 Sep 2011 06:16
Last Modified: 18 Oct 2011 06:47
URI: http://eprints.manipal.edu/id/eprint/1292

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