A Study of High-Sensitivity C-Reactive Protein in Bronchial Asthma

Sahoo, Ramesh Chandra and Acharya, Preetam Rajgopal and *, Noushad T.H. and *, Anand R and Acharya, Vishak K. and Sahu, Kausalya R. (2009) A Study of High-Sensitivity C-Reactive Protein in Bronchial Asthma. The Indian Journal of Chest Diseases & Allied Sciences, 51. pp. 213-216.

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Background. Relevance of C-reactive protein an acute phase reactant and a sensitive marker of low-grade systemic inflammation in bronchial asthma has not been fully studied. Objective. To evaluate the significance of high-sensitivity C-reactive protein (hs-CRP) in atopic and non-atopic asthma using an ultra sensitive assay. Methods. The levels of hs-CRP of 200 patients with bronchial asthma and 50 non-asthmatic control subjects were measured using a Latex enhanced immunoturbidimetric test. Spirometry with reversibility study, serum immunoglobulin-E (IgE) measurement and skin test for allergy was done in all the patients. Results. There was a significant increase in hs-CRP levels with age in atopic asthmatics but no such association was observed in the non-atopic asthmatics and control subjects. The hs-CRP levels were not influenced by sex in any group. Smokers in all the three groups had a significantly higher hs-CRP levels as compared to non-smokers. Patients with asthma had higher hs-CRP values as compared to controls. Patients with non-allergic asthma had higher mean hs-CRP as compared to atopic asthmatics and control subjects. Conclusions. The study suggests that there exists a certain degree of low-grade systemic inflammation in addition to the local bronchial inflammation in non-atopic asthmatics. Hence, hs-CRP may be used as a surrogate marker for the airway inflammation in non-atopic asthma patients.

Item Type: Article
Uncontrolled Keywords: C-reactive protein, High-sensitivity C-reactive protein, Non-atopic asthma, Acute phase proteins.
Subjects: Medicine > KMC Mangalore > Pathology
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 31 May 2013 09:59
Last Modified: 25 Oct 2016 08:46
URI: http://eprints.manipal.edu/id/eprint/136193

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