Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: potential applications

Narasimhaswamy, Nagalakshmi (2013) Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: potential applications. Veterinary Research Communications. ISSN 0165-7380

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Abstract

In this study, we demonstrate the antibacterial activity of P128 on Staphylococcus isolates responsible for canine pyoderma. Eighty seven swabs were collected from dogs suffering from pyoderma and subjected to antibiotic sensitivity test and 46 Staphylococcus strains were isolated and characterized. In-vitro antimicrobial susceptibility testing with P128 was done by Minimum Inhibitory Concentration (MIC) method as per CLSI guidelines. All the Staphylococci isolated from the dogs with pyoderma, although showed resistance to various antibiotics tested, were lysed by P128. Clinical efficacy of P128 was examined in 17 dogs with pyoderma by application of the P128 hydrogel twice daily for 8 days and the results indicated complete healing of all the lesions of all the dogs under treatment. Under the conditions of this study, P128 was found to be a potent convenient proteinaceous drug for the treatment of staphylococcal pyoderma in dogs.

Item Type: Article
Uncontrolled Keywords: Antibiotic resistant Staphylococci; Canine pyoderma; Coagulase positive staphylococci; Coagulase negative staphylococci; P128 hydrogel; Staphylococcus intermedius; Staphylococcus pseudintermedius.
Subjects: Medicine > MMMC Manipal > Microbiology
Depositing User: KMC Manipal
Date Deposited: 05 Jun 2013 04:25
Last Modified: 05 Jun 2013 04:25
URI: http://eprints.manipal.edu/id/eprint/136227

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