Effect of bilateral lesions of nucleus accumbens on consummatory behaviour in Wistar rats

Mayannavar, Santhosh K. and *, Rashmi K. Shiva and Aithal, Keerthi and Bhat, Ramesh M and *, Ganaraja B (2013) Effect of bilateral lesions of nucleus accumbens on consummatory behaviour in Wistar rats. Journal of pharmacy research , 7. 263 -266.

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Abstract

Background: Nucleus accumbens (NAcc) is known to be involved in reward and addictive functions. In the present study we tested parameters of ingestive activity and alcohol intake following lesions of nucleus accumbens in order to establish the role of this nucleus unequivocally. Materials and methods: Male Wistar albino rats were divided into groups, and were subjected to Sham lesion and bilateral lesion of nucleus accumbens. The consumption of water, ethanol and food were recorded daily and their body weight was noted weekly, for one week before lesion and 3 weeks following lesion. In another set, two bottle free choice test was carried out between 10% alcohol and potable water, rest of the procedures were maintained same as for the other set. Results: The lesioned rats showed increase in intake of alcohol ( p < 0.01). There was no significant change in food intake or body weight. In two bottle free choice test, the rats consumed increased volume of fluid. There was highly increased water intake ( p < 0.001). There was no significant change in their alcohol intake. The increase in water intake was significantly more than the increase seen in the alcohol intake in the group provided only alcohol. Conclusions: Bilateral lesions in nucleus accumbens did not change the alcohol intake in two bottle choice test. But they showed increased water intake in two bottle choice suggesting increased thirst. The alcohol intake increases only when there is no water provided, suggesting the pivotal role of this centre in ingestive behaviour.

Item Type: Article
Uncontrolled Keywords: Ingestive behaviour, Nucleus accumbens, Alcohol consumption, Water intake
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 21 Jun 2013 06:02
Last Modified: 21 Jun 2013 06:02
URI: http://eprints.manipal.edu/id/eprint/136345

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