Clinicopathological Analysis of Pheochromocytoma: A Retrospective Study

Shenoy, Gokuldas M and Karthikeyan, Selvaraju (2013) Clinicopathological Analysis of Pheochromocytoma: A Retrospective Study. WebmedCentral ENDOCRINE SURGERY, 4 (3). pp. 1-12. ISSN 2046-1690

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Abstract

Pheochromocytoma is a rare tumor of chromaffin tissues most commonly arising from the adrenal medulla. We retrospectively reviewed the records of 34 patients with pheochromocytoma who underwent surgical treatment between 1971 and 2006. Fourteen patients (41.2%) were females and twenty (58.8%) were males. The most frequent symptoms were Hypertension (97%) and palpitation (38.2%). Seven patients had an extra-adrenal tumor and in one patients the tumor occurred in the urinary bladder. Nine patients (26.5%) had persistent hypertension, 11 patients (32.4%) had paroxysmal hypertension and 13 patients (38.2%) had persistent with paroxysms. The 24-h urinary total metanephrines and vanillylmandelic acid (VMA) were the most sensitive biochemical tests for the diagnosis of pheochromocytoma. One of our patients was found to be associated with hereditary pheochromocytoma syndrome. All hypertensive patients were preoperatively treated with phenoxybenzamine and propranolol. All underwent explorative laparotomy and adrenelectomy. All patients were followed up with 24-h urinary VMA levels and CT scan of abdomen regularly.

Item Type: Article
Uncontrolled Keywords: Adrenal mass;Neuroectodermal tumor;Pheochromocytoma
Subjects: Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 27 Jun 2013 04:21
Last Modified: 27 Jun 2013 04:21
URI: http://eprints.manipal.edu/id/eprint/136399

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