Effect of HAART on hematological profile of pediatric HIV patients

Bhat, Kamalakshi G. and *, Shwetha Seetharam (2013) Effect of HAART on hematological profile of pediatric HIV patients. Karnataka Journal of Pediatrics, 28 (1). pp. 16-20.

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Abstract

Objective: To study the effect of HAART on the haematological profile in pediatric HIV patients. Study Design: Prospective hospital based cross sectional study. Patients: 40 children between 2-15 yrs of age with HIV who are eligible for HAART based on WHO recommendations with baseline blood counts and transaminases within the normal range were studied for a period of 6 months. Results: Out of 40 children, with a mean age of 8.63 years, who were a part of this study, one child expired after completing 3 months of HAART and 2 children who were on zidovudine , had to have drug substitutions due to severe anemia. A significant rise in the mean hemoglobin levels was noted. One case developed thrombocytopenia (51,000/cumm) after 3 months of HAART. A significant fall in the mean hemoglobin from 10.3mg/dl to 9.6mg/dl was seen in those children who were on zidovudine as compared to a rise in the hemoglobin level seen in those who were not on the drug. Conclusion: HAART improves the hematological parameters especially haemoglobin and CD4 counts. Inclusion of zidovudine in the HAART has a higher incidence of drug induced anemia. Neutropenia (ANC<500/cumm) was not seen in any of the cases.

Item Type: Article
Uncontrolled Keywords: HAART, heamatological, pediatric HIV
Subjects: Medicine > KMC Mangalore > Paediatrics
Depositing User: KMCMLR User
Date Deposited: 02 Jul 2013 10:10
Last Modified: 02 Jul 2013 10:10
URI: http://eprints.manipal.edu/id/eprint/136425

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