Nagamma, T (2012) Influence of Alcohol Consumption on Oxidative Stress and Antioxidant Status in Cancer Patients - Case-control Study from Western Nepal. Asian Pacific Journal of Cancer Prevention, 13 (7). pp. 3513-3517.
![]() |
PDF
3513-17 6.8 Nagamma.pdf - Published Version Restricted to Registered users only Download (410kB) | Request a copy |
Abstract
Aim: The present study assess the effect of consumption of alcohol on oxidative stress and antioxidant status in patients suffering from different types of cancer. Methods: This hospital based case control study conducted in the Western part of Nepal covered a total of 93 cancer patients with or without alcohol intake and smoking habits, along with 94 age, sex and habit-matched individuals serving as controls. Plasma thiobarbituric acid reacting substances (TBARS), total antioxidant activity (TAA), vitamin C, α-tocopherol and erythrocyte reduced glutathione (GSH) were estimated and compared. Results: The TBARS level was found to be significantly higher (p≤0.001) in all types of cancer patients when compared to controls, being aggravated in alcoholics with a smoking habit. No statistical significance (p≥0.05) was observed in the level of vitamin C and α-tocopherol. GSH and TAA level were significantly decreased (p≤0.001) in all the groups except those who consumed both branded as well as homemade alcohol and non-alcoholics without smoking habit. Conclusion: Alcohol, irrespective of its commercial brand, increases oxidative stress in all types of cancer patients. This is even higher when alcohol intake is combined with a smoking habit. Decreased TAA and GSH are major risk factors for cancer development.
Item Type: | Article |
---|---|
Uncontrolled Keywords: | Alcohol; oxidative stress; antioxidants; cancer; Western Nepal. |
Subjects: | Medicine > MMMC Manipal > Biochemistry |
Depositing User: | KMC Manipal |
Date Deposited: | 06 Jul 2013 06:59 |
Last Modified: | 06 Jul 2013 06:59 |
URI: | http://eprints.manipal.edu/id/eprint/136460 |
Actions (login required)
![]() |
View Item |