Anti-microbial studies on novel 1, 3-oxazolidine analogs

Vachala, Dinakaran and Mathew, Jessy Elizabeth and Sivagurunathan, N (2008) Anti-microbial studies on novel 1, 3-oxazolidine analogs. Pharmacologyonline, 2. pp. 192-197.

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In present study several substituted 1, 3-oxazolidines were synthesized by condensation of reduced Schiff base of phenylglycinol with different aldehydes. All the synthesized compounds showed good to moderate antimicrobial activity. The antimicrobial activites were performed by disc diffusion method and minimum inhibitory concentration determination by serial agar dilution method. Thus among the ten compounds, 3-[3-2- furyl methyl)-4-phenyl- 1,3-Oxazolidin-2-yl]-1H-indole (4a), 2-(2-furyl)-3-(2-furyl methyl)-4-phenyl-1,3-Oxazolidine (4b) and 4-[3-(2 furylmethyl)-4-phenyl-1,3- oxazolidin-2-yl]-2-methoxy phenol (4h) were found to have a moderate to significant antimicrobial activity against all the strains used. Compound 2-(4-chlorophenyl)-3-(2- furylmethyl)-4-phenyl-1, 3-oxazolidine (4j) showed very good antifungal activity than the other compounds tested. Further more, compounds containing -Cl-, -OCH3, -OH groups as substituents were found to be potent antimicrobial agents. Moreover the heteroaromatic substitutions also showed very good antimicrobial activities.

Item Type: Article
Uncontrolled Keywords: synthesis; oxazolidines; antibacterial; antifungal; aldehydes.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 06 Jul 2013 07:03
Last Modified: 06 Jul 2013 07:03

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