Protein Thiols and Butryrylcholinestrase in Saliva of Oral Cancer Patients

Chianeh, Yousef Rezaei and Rashmi, Manjunath and Prabhu, Krishnananda and Fernandes, Donald J and Vidyasagar, MS and Kamath, Asha (2013) Protein Thiols and Butryrylcholinestrase in Saliva of Oral Cancer Patients. Indian Journal of Clinical Biochemistry. ISSN 0974-0422

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Abstract

Oral squamous cell carcinoma is one of the most common malignancies recognized. Biomarkers which can predict presence of cancer and its progression can help in better management of these disorders. Over production of lipid peroxidation byproducts and disturbances in antioxidant defense system have been implicated in the pathogenesis of several diseases including oral cancer. Studies have shown a correlation of butyrylcholinesterase (BChE), with tumourigenesis, cell proliferation and cell differentiation.Earlier we have observed a significant elevation in plasma BChE and protein thiols in oral cancer patients which correlated well with stages of cancer. As it was not clear whether the above markers will be altered in saliva of oral cancer patients this study was undertaken. Institutional Ethics Committee gave permission to carry out this study. Total of 55 subjects comprising healthy controls (n = 30) and biopsy proven oral cancer patients (n = 25) consented to participate in this study. Salivary samples from cases were taken before any definitive treatment. Protein thiols and BChE were estimated in salivary samples using validated assay methods. Oral cancer patients had a significant increase in pre-treatment salivary BChE levels (p B 0.001)and a significant decrease (p B 0.001) in salivary thiols as compared to respective values in controls. Salivary protein thiols and BChE may have a role in pathophysiology of oral cancer. Saliva can be used as a potential non-invasive screening tool in oral cancer patients.

Item Type: Article
Uncontrolled Keywords: Oral squamous cell carcinoma; Saliva;Protein thiols; Butyrylcholinesterase
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Community Medicine
Medicine > KMC Manipal > Radiotherapy and Oncology
Depositing User: KMC Manipal
Date Deposited: 22 Jul 2013 04:20
Last Modified: 17 Oct 2013 10:18
URI: http://eprints.manipal.edu/id/eprint/136611

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