Synbiotic formulation of probiotic and lactulose combination for hepatic encephalopathy treatment: A realistic hope?

Sekhar, Sonal M and Unnikrishnan, MK and Rodrigues, Gabriel and Mukhopadhyay, Chiranjay (2013) Synbiotic formulation of probiotic and lactulose combination for hepatic encephalopathy treatment: A realistic hope? Medical Hypotheses, 81 (2013). pp. 167-168.

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Abstract

Gut-produced ammonia plays a vital role in the pathogenesis of hepatic encephalopathy because cirrhotic liver fails to clear toxic metabolites. Small intestinal bacterial overgrowth and delayed gastrointestinal transit time in cirrhosis add to the pathogenesis. Lactulose is a mainstay in the treatment of hepatic encephalopathy. Another benefit of lactulose is its prebiotic effect on probiotics that reduce the activity of bacterial urease, resulting in decreased hyperammoneamia and increased elimination of ammonia and other nitrogenous waste through enteric toxin reduction technology. Synbiotic formulation of probiotic and lactulose can synergistically/additively reduce ammonia production, increase utilization and excretion of ammonia and other nitrogenous wastes, thereby improving the well-being of patients with hepatic encephalopathy. We hypothesize that oral administration of a synbiotic formulation prepared from a combination of selected microbial strains of probiotics and lactulose will offer additional protection against hepatic encephalopathy via intra-intestinal extraction of toxic solutes in patients with cirrhosis.

Item Type: Article
Subjects: Medicine > KMC Manipal > Microbiology
Pharmacy > MCOPS Manipal > Pharmacy Practice
Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 24 Jul 2013 09:19
Last Modified: 27 Mar 2015 07:25
URI: http://eprints.manipal.edu/id/eprint/136633

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