Effect of Moringaoleifera leaf extract on cadmium induced renal toxicity in adult Wistar Albino rats

Chatterjee, Pratik Kumar and *, Vinodini N.A and Singh, Ranjith and *, Rakshatha R and *, Anwar Amemarsoofi and Pai, Sheila R (2013) Effect of Moringaoleifera leaf extract on cadmium induced renal toxicity in adult Wistar Albino rats. International Journal of Advanced Research, 1 (5). pp. 162-165. ISSN 2320-5407

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Abstract

Cadmium (Cd), a transitional metal, is an important industrial & environmental toxicant, adversely affecting various organs like liver, lungs, pancreas, testis, kidneys, etc., It has been found to cause a definitive oxidative stress on the kidneys of studied rats. Moringaoleifera, a perennial softwood herbal plant, having anti-oxidant, anti- inflammatory properties, etc., which has been advocated for centuries for its nutritional, medicinal & industrial uses, is most oftenlyused to combat toxicity of these materials.The present study was designed to find out the effect of aqueous leaf extract of Moringaoleiferaon kidney functions in cadmium exposed adult wistar rats. Four groups were allotted, with group I being the control. Pre-treatment with Moringaoleiferaleaf extract in cadmium exposed rats showed a significant decrease in the levels of serum urea&serum creatinine levels as compared to the cadmium alone treated rats. Therefore, the present study suggests that pre-treatment with Moringaoleiferaleaf extract improves the kidney functions which were affected by the toxic effect of cadmium. However, further investigations are needed to know the detailed mechanisms triggering these effects.

Item Type: Article
Uncontrolled Keywords: Cadmium, Moringaoleifera, kidney, urea, creatinine
Subjects: Medicine > KMC Mangalore > Physiology
Depositing User: KMCMLR User
Date Deposited: 03 Aug 2013 10:25
Last Modified: 03 Aug 2013 10:25
URI: http://eprints.manipal.edu/id/eprint/136730

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