Comparison of Post-Operative Analgesic Effects of Pre-Operative Pregabalin with Diclofenac in Head and Neck Surgery

Rao, Sumesh T and Wali, Murugesh and Sachan, Vertika and Upadya, Madhusudan (2013) Comparison of Post-Operative Analgesic Effects of Pre-Operative Pregabalin with Diclofenac in Head and Neck Surgery. Inernational Journal of Scientific Research, 2 (8). pp. 319-322. ISSN 2277 - 8179

[img] PDF
head & neck surgery.pdf - Published Version
Restricted to Registered users only

Download (458kB) | Request a copy

Abstract

Background: Study conducted to compare effects of pre-emptive pregabalin with diclofenac on post-operative after head and neck surgery. Side effects assessed, and hemodynamics for 24 hrs post-operatively observed. Methods: Prospective, randomized, placebo-controlled clinical study on 66 ASA 1 and 2 patients between 18-60 yrs posted for elective head and neck procedures. Patients were randomized in two groups. Pre-emptive analgesia was given 1 hr before surgery with • 75 mg diclofenac orally • 150 mg pregabalin orally Primary outcomes were severity of postoperative pain, and postoperative analgesic requirement (IM diclofenac 75mg). Secondary outcomes were incidence and severity of side-effects. Results: Patients in the pregabalin group: had less post-operative pain in the 12 - 24 hour period, were sedated more during the first 8 hrs, and less of them needed postoperative rescue analgesic, in lower doses. Conclusion: Oral pregabalin 150 mg administered pre-operatively was more effective in reducing postoperative pain and rescue analgesic requirement in patients undergoing elective Head and Neck Surgeries compared to diclofenac.

Item Type: Article
Uncontrolled Keywords: pre-emptive analgesia, diclofenac, pregabalin
Subjects: Medicine > KMC Mangalore > Anaesthesiology
Depositing User: KMCMLR User
Date Deposited: 06 Aug 2013 06:34
Last Modified: 06 Aug 2013 06:34
URI: http://eprints.manipal.edu/id/eprint/136739

Actions (login required)

View Item View Item