Comparison of effects of preoperative piroxicam and ibuprofen on pain after separator placement: A randomized controlled trial

Shetty, Siddarth and Shenoy, Nandita and Shenoy , Ashok Kudgi and *, Unnikrishnan B and Mogra, Subraya (2013) Comparison of effects of preoperative piroxicam and ibuprofen on pain after separator placement: A randomized controlled trial. Journal of Social Health and Diabetes, 1 (2). pp. 57-61. ISSN 2321-3825

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Abstract

Introduction: Orthodontic therapy causes signifi cant pain for a large percentage of patients. It is one of the main reasons that discourage patients from seeking orthodontic treatment. Pain during orthodontic treatment may have a negative infl uence on cooperation and can also reduce the compliance. This study assessed the effectiveness of a single dose of preoperative Piroxicam in reducing the incidence and severity of pain after orthodontic separator placement when compared to ibuprofen. Materials and Methods: The study was a randomized, placebo-controlled, double-blind, parallel-arm study. Sixty eight patients were recruited for this study and were randomly assigned to one of the three experimental groups: 1. 20 mg of Piroxicam followed by two doses of multivitamin placebo (n = 30); 2. 400 mg of Ibuprofen in three doses (n = 20) and 3. A multivitamin placebo (n = 18). All the three groups were administered the fi rst dose of the respective medication one hour prior to separator placement, the successive two doses were given at 3 hours and 7 hours after separator placement. The pain experienced by the patient was assessed at the time intervals 2 hours, 4 hours, 6 hours, bedtime, on awakening the following day and 24 hours after administration using a visual analogue scale. Results: A comparison of pain perception between all three groups with the repeated measures analysis of variance (ANOVA) and a comparison of pain perception between the fi rst and second group using the Student t test revealed that preemptive Piroxicam therapy signifi cantly lower pain levels experienced at all-time intervals starting from 2 hours after separator placement till 24 hours after placement. Conclusion: A single dose of Piroxicam taken 60 minutes before separator placement reduces pain due to separator placement experienced in the fi rst 24 hours following separator placement.

Item Type: Article
Uncontrolled Keywords: Orthodontic pain, preemptive analgesic, piroxicam, separator placement
Subjects: Dentistry > MCODS Mangalore > Oral Medicine and Radiology
Depositing User: KMCMLR User
Date Deposited: 13 Aug 2013 05:04
Last Modified: 13 Aug 2013 05:04
URI: http://eprints.manipal.edu/id/eprint/136813

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