Synthesis and Crystal structure studies of Diethyl-(6-chloro-2-carbazolyl)Methyl malonate an intermediate in the synthesis of Anti-inflammatory drug Carprofen

Gaonkar, Santosh L and Mahendra, M and Swamy, Nanjunda S and Shetty, Nitinkumar S (2012) Synthesis and Crystal structure studies of Diethyl-(6-chloro-2-carbazolyl)Methyl malonate an intermediate in the synthesis of Anti-inflammatory drug Carprofen. Research Journal of Pharmaceutical Sciences, 1 (1). pp. 16-22. ISSN 2319 - 555X

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Abstract

Diethyl-(6-chloro-2-carbazolyl)methyl malonate, an intermediate in the synthesis of anti-inflammatory drug Carprofen and number of biologically active heterocycles, was synthesized and X-ray studies have been performed. The crystal structure analysis shows the title compound crystallizes in triclinic class under the space group P-1 with cell parameters, a =9.3408(11) °A, b = 10.4853(12) °A, c = 11.1601(13) °A � = 113.623(6)�, � = 105.130(6)�, � = 93.040(6)� and Z=2. The molecule exhibits N-H-O type intermolecular hydrogen bond.

Item Type: Article
Uncontrolled Keywords: Anti-inflammatory drug carprofen biologically active heterocycles, intermolecular hydrogen bond
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 21 Aug 2013 06:23
Last Modified: 21 Aug 2013 06:23
URI: http://eprints.manipal.edu/id/eprint/136842

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