Coexistent gastric primary choriocarcinoma and adenocarcinoma

Pai, Muktha R and Mathai, Alka M. and *, Suneet Kumar and Prabhu, Shivananda (2009) Coexistent gastric primary choriocarcinoma and adenocarcinoma. Indian Journal of Pathology & Microbiology, 52 (4). pp. 537-539. ISSN 0377-4929

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Abstract

Choriocarcinomas are commonly gestational and intrauterine or gonadal in origin. Nongestational and extragonadal disease, especially in the stomach is extremely rare with a poorer prognosis and early metastasis. We herein describe a case of primary gastric choriocarcinoma with liver metastasis in a 69-year-old male. The patient presented with abdominal pain and irregular bowel habits of one month duration. Both endoscopic and radiographic imaging revealed an ulcerated and necrotic circumferential tumor in the pyloric antrum of the stomach. The histopathologic fi ndings of the resected tumor were that of an extensively necrotic and hemorrhagic neoplasm with combined choriocarcinomatous and adenocarcinomatous element. A strongly positive immunohistochemical staining for β- subunit of human chorionic gonadotropin (β-HCG) in the choriocarcinomatous component and a proper correlation with elevated serum β-HCG levels confi rmed the diagnosis.

Item Type: Article
Uncontrolled Keywords: Adenocarcinoma, choriocarcinoma, gastric tumor, β-human chorionic gonadotropin, liver metastasis
Subjects: Medicine > KMC Mangalore > Pathology
Medicine > KMC Mangalore > Surgery
Depositing User: KMCMLR User
Date Deposited: 23 Aug 2013 06:11
Last Modified: 23 Aug 2013 06:11
URI: http://eprints.manipal.edu/id/eprint/136852

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