Antioxidant activity of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on free radical scavenging in vitro models

Satyam, Shakta Mani and Bairy, KL (2013) Antioxidant activity of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on free radical scavenging in vitro models. Jokull Journal, 63 (5). pp. 360-369. ISSN 0449-0576

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Abstract

The present study was aimed at investigating the dose dependent free radical scavenging activity of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) using different in vitro models. In vitro antioxidant activity was measured by two methods, 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and [2,2-azinobis(3-ethyl-benzothiazoline-6-sulphonic acid)] (ABTS) radical scavenging assay. Various concentrations of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) dissolved in methanol (1.56-250μg/ml) were used. Ascorbic acid was used as a standard drug. Methanol and water were served as blank. In DPPH and ABTS radical scavenging assays, the IC50 values were 74.70μg/ml and 23.66μg/ml respectively. In both the methods a significant correlation existed between concentrations of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) and percentage inhibition of free radicals. The results obtained in this study indicate that the combination of Grape seed extract and Zincovit tablets (nutritional food supplement) is a potential source of natural antioxidant.

Item Type: Article
Uncontrolled Keywords: Grape seed extract; Zincovit; antioxidant.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 22 Aug 2013 09:18
Last Modified: 22 Aug 2013 09:18
URI: http://eprints.manipal.edu/id/eprint/136867

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