Novel intervention to improve adherence to medication in diabetic patients:formulation and evaluation of metformin HCL novel dosage form

Kandi, Manisha and Sivasai, Gayathri and Rathnanand, Mahalaxmi and Reddy, Sreenivasa M and Bhasker, Vijaya K (2013) Novel intervention to improve adherence to medication in diabetic patients:formulation and evaluation of metformin HCL novel dosage form. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (3). pp. 587-592. ISSN 0975-1491

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Abstract

Objective: The aim of the present study was to prepare the chewable Metformin HCl formulation to overcome patient’s non-adherence to prescription pattern in diabetes. Chewable tablets provide hassle free approach to diabetic patients to take medication during social gatherings or travelling because of discomfort in carrying or administration. Method: Chewable Metformin HCl sustained release tablets were prepared using ethyl cellulose and stearic acid/ glycerol monostearate as release retarding agents.Stevia is selected as sweetening agent as its extracts are not absorbed by the digestive tract, so they do not add calories or affect blood glucose levels. Results: Various evaluation parameters like thickness, hardness, friability weight variation and drug content of the formulations were found to be satisfactory. Among all formulations prepared andevaluated MS-05 appeared to have desired release pattern than others.DSC (Differential Scanning Calorimetry) and IR (Infra-red) studies showed no interaction between drug and excipients in optimized formulation. Formulation MS-05 matches with the innovator product with the similarity factor value 58.65. Release kinetics of optimized formulation follows first order, Higuchi and Kosmeyear- peppas non-fickian diffusion. The optimized tablets found to be stable under accelerated conditions for a period of one month. Conclusion: The release study of both crushed and intact MS-05 tablet showed similar release rate which supports that even if patient swallows the formulation during chewing, the drug release pattern and thereby the drug absorption may not be affected.

Item Type: Article
Uncontrolled Keywords: Patients non adherence; Chewable tablets; Stevia.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 26 Aug 2013 04:10
Last Modified: 26 Aug 2013 04:10
URI: http://eprints.manipal.edu/id/eprint/136883

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