Influence of Grape Seed Extract and Zincovit Tablets(nutritional food supplement) on Glucose level in Normal and Streptozocin Induced Diabetic Rats

Satyam, Shakta mani and Bairy, KL and Pirasanthan, Rajadurai (2013) Influence of Grape Seed Extract and Zincovit Tablets(nutritional food supplement) on Glucose level in Normal and Streptozocin Induced Diabetic Rats. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (3). pp. 413-416. ISSN 0975-1491

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INFLUENCE OF GRAPE SEED EXTRACT AND ZINCOVIT TABLETS (NUTRITIONAL FOOD SUPPLEMENT) ON GLUCOSE LEVEL IN NORMAL AND STREPTOZOCIN INDUCED DIABETIC RATS.pdf - Published Version
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Abstract

Objective: To evaluate the influence of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) on blood glucose level in normal and streptozocin induced diabetic rats.Method: A total of 48 adult male Wistar rats (24 normal rats, 24 diabetic surviving rats) were divided into 8 groups of 6 rats each. Experimental hyperglycemia was produced in rats by single dose of Streptozocin (35 mg/kg; i.p). Assessment of glucose in blood and urine of rats was used as marker of hyperglycemia.Results: Oral administration of combination of Grape seed extract and Zincovit tablets (nutritional food supplement) for 45 days significantly reduced the levels of blood glucose in a dose dependent manner among diabetic treated rats when compared to diabetic control rats (P<0.0001, at 40 mg/kg, 80 mg/kg and 160 mg/kg) whereas it had significantly increased the blood glucose level in normal treated rats in comparison with normal control rats (P=0.011, 0.003 and 0.029 at 40 mg/kg, 80 mg/kg and 160 mg/kg respectively). There was significant increase in the weight of isolated dry liver among diabetic treatment group when compared to diabetic control in a dose dependent manner. There was no significant body weight change in diabetic and normal rats as compared to diabetic control and normal control rats respectively.Conclusion: The hypoglycemic effect of combination of Grape seed extract and Zincovit tablets may be attributed to enhanced antioxidant potential and protection against tissue lipid peroxidation and protein oxidation.

Item Type: Article
Uncontrolled Keywords: Zincovit;Grape seed extract; Streptozocin; Hyperglycemia; Diabetes
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 26 Aug 2013 04:08
Last Modified: 26 Aug 2013 04:08
URI: http://eprints.manipal.edu/id/eprint/136885

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