Synchronous colorectal neoplasms in ulcerative pancolitis of 6 years duration: pathological and molecular heterogeneity

Shivakumar, BM and Rao, Lakshmi and Satyamoorthy, K and Pai, Ganesh C (2013) Synchronous colorectal neoplasms in ulcerative pancolitis of 6 years duration: pathological and molecular heterogeneity. BMJ Case Reports. pp. 1-4.

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Abstract

Colorectal cancer (CRC) complicating ulcerative colitis (UC) accounts for about 1% of all cases of CRC. Such tumours develop from pre-existing foci of dysplasia in patients with extensive and long-standing UC. We report a case of UC-associated synchronous CRC and foci of high-grade dysplasia with an additional malignant focus in the appendix in a female patient after only 6 years of pancolitis who did not have other risk factors for the development of complications. The multiplicity and the timings of the early changes noted suggest that longstanding inflammation in UC randomly damages multiple genes in epithelial cells known to contribute to colorectal carcinogenesis. Current findings also support a molecular and pathological heterogeneity during multiclonal origin of synchronous tumours whereby differences occur at various sites that were absent during the initial stages of the disease.

Item Type: Article
Subjects: Medicine > KMC Manipal > Gastroenterology
Life Sciences > MLSC Manipal
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 02 Sep 2013 04:34
Last Modified: 02 Sep 2013 04:34
URI: http://eprints.manipal.edu/id/eprint/137008

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