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Haloperidol Versus Granisetron for Prophylaxis of Post-Operative Nausea and Vomiting. - A Double Blind Prospective Randomised Study

*, Suhas Ramaswamy and *, Narendra and Upadya, Madhusudan (2013) Haloperidol Versus Granisetron for Prophylaxis of Post-Operative Nausea and Vomiting. - A Double Blind Prospective Randomised Study. International Journal of Scientific Research, 2 (9). pp. 293-295. ISSN 2277-8179

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Abstract

Background: Haloperidol a Butyrophenone with a high affinity for Dopamine D2 receptors has a strong antiemetic property. Materials and methods: 90 ASA I-II patients aged 18-65yrs scheduled for elective laparoscopic surgeries were randomized into three groups. Group H received Haloperidol1mg, Group G received Granisetron 1mg .Group C received no antiemetics. Anaesthesia was standardized. Recovery time, sedation level, pain score, nausea score, episodes of vomiting, rescue antiemetics,ECG and other side effects were evaluated. Results: There was no significant difference in nausea and vomiting between haloperidol group and granisetron group. Sedation score was significantly more in haloperidol compared to granisetron but recovery was not statically significant. 6 cases (20%) in granisetron group had headache, which is statistically significant. Conclusion: Haloperidol provides antiemetic protection during the peak incidence of post-operative nausea and vomiting (PONV).Antiemetic doses of haloperidol is safe.

Item Type: Article
Uncontrolled Keywords: Antiemetic Prophylaxis, Haloperidol, Granisetron
Subjects: Medicine > KMC Mangalore > Anaesthesiology
Depositing User: KMCMLR User
Date Deposited: 18 Sep 2013 11:32
Last Modified: 18 Sep 2013 11:32
URI: http://eprints.manipal.edu/id/eprint/137220

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