Effect on antioxidant defense system in contra-lateral kidney after unilateral renal vessel occlusion in rats

*, Vinodini N.A and *, Yogesh Tripathi and *, Raghuveer CV and Kamath, Asha and Chatterjee, Pratik Kumar (2013) Effect on antioxidant defense system in contra-lateral kidney after unilateral renal vessel occlusion in rats. International Journal of Advanced Research, 1 (6). pp. 6-12. ISSN 2320-5407

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Abstract

Aim: T0 evaluate the effect of unilateral renal reperfusion injury following ischemia on contralateral kidney either in presence or absence of free radical scavengers. Materials & method: Seven Wistar Albino rats in each group underwent unilateral renal ischemia of left renal vessels using occluder for 60 minutes of ischemia followed by 10 & 90 minutes respectively of reperfusion & the biochemical parameters such as MDA, SOD, GSH &ceruloplasmin levels were measured in the contralateral as well as occluded kidney either in the presence or absence of free radical scavengers . Result: A significant increase in MDA & a decrease in GSH, SOD &ceruloplasmin levels in the tissues was observed in the occluded kidney. However, the levels of the above mentioned parameters in the contra- lateral renal tissue did not show any significant effect following 10 & 90 minutes of reperfusion. Conclusion: Therefore, the results of present study showed that 60 minutes of renal ischemia followed by reperfusion for 10 & 90 minutes respectively had no significant effect on the antioxidant defense system of the contra-lateral kidney.

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