Antioxidant activity of novel coumarin substituted benzothiazole derivatives

Choudhary, Shivani and Kini, Suvarna G and Mubeen, Muhammad (2013) Antioxidant activity of novel coumarin substituted benzothiazole derivatives. Der Pharma Chemica, 5 (4). pp. 213-222. ISSN 0975-413X

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An attempt was made to synthesize newer coumarin substituted derivatives of benzothiazole and they were evaluated for antioxidant activity by DPPH radical scavenging activity. The test compound SC-7 showed good in-vitro antioxidant activity. The same compound was selected for in-vivo antioxidant studies by administering different doses in Ehrlich Ascites Carcinoma (EAC) treated mice. It reduced the levels of lipid peroxidation and increased the GST contents as well as CAT levels in EAC induced mice. The present study revealed that newly synthesized coumarin substituted benzothiazole derivatives showed significant antioxidant activity in EAC bearing mice.

Item Type: Article
Uncontrolled Keywords: Coumarin; benzothiazole; antioxidant; DPPH radical scavenging; lipid peroxidation.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 21 Sep 2013 04:08
Last Modified: 21 Sep 2013 04:08

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