Formulation And Evaluation Of Chewable Tablet Of Metformin HCl Using Stevia By Different Techniques

Kandi, Manisha and Sivasai, Gayathri and Rathnanand, Mahalaxmi and Reddy, Sreenivasa M (2013) Formulation And Evaluation Of Chewable Tablet Of Metformin HCl Using Stevia By Different Techniques. International Journal of PharmTech Research, 5 (3). pp. 1364-1372. ISSN 0974-4304

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Abstract

Stevia, a non-caloric sweetener and flavour enhancer. Stevia was originally available as a "dietary supplement".It is used as a weight loss aid; for treating diabetes, high blood pressure and heartburn; and for increasing the strength of the muscle contractions that pump blood from the heart.Its extracts are not absorbed by the digestive tract, so they do not add calories or affect blood glucose levels, making them a good addition to blood glucose levels. Therefore present work is an attempt to formulate an anti-diabetic drug metformin as a chewable tablet which helps to improve patient’s adherence towards medication. Various evaluation parameters like thickness, hardness, friability weight variation and drug content of the formulations were found to be satisfactory. Release profile of the optimized formulations which were prepared by wet granulation technique showed satisfactory release within 30 minutes.The variation in the dissolution rate of Metformin chewable tablets made by different techniques were in the following order, direct compression< non-aqueous granulation< aqueous granulation. Chewable immediate release Metformin tabletDSC (Differential Scanning Calorimetry) and IR (Infra-red) studies showed no interaction between drug and excipients in optimized formulation.The optimized tablets found to be stable under accelerated conditions for a period of one month.

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 23 Sep 2013 04:00
Last Modified: 23 Sep 2013 04:00
URI: http://eprints.manipal.edu/id/eprint/137257

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