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Serum C peptide level and renal function in diabetes mellitus.

*, Chowta M N and *, Adhikari P M and *, Chowta N K and *, Shenoy A K and *, D’Souza S (2010) Serum C peptide level and renal function in diabetes mellitus. Indian Journal of Nephrology., 20 (1). pp. 25-28. ISSN 0971-4065

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Abstract

C peptide is an active peptide hormone with potentially important physiological effects. C peptide has the capacity to diminishglomerular hyperfiltration and reduce urinary albumin excretion in both experimental and human type 1 diabetes. The presentstudy is aimed at correlating the serum C peptide level with that of renal clearance, urinary albumin excretion and duration ofdiabetes. This is a prospective cross sectional study. Patients with diagnosis of type 2 diabetes mellitus were evaluated fortheir baseline clinical and laboratory profile. Both males and females above the age of 18 years were included in the study.The laboratory investigations include fasting serum C peptide, HbA1C, serum creatinine, blood urea nitrogen, urine albumin and creatinine. Creatinine clearance was calculated using modification of diet in renal disease formula from serum creatinine value.A total of 168 patients were included in the study, among them 90 were females (53.57%) and 78 males (46.43%). Mean ageof the patients was 57.64 years. Pearson correlation test showed negative correlation of serum C peptide level with creatinineclearance, though statistically not significant. Negative correlation was also seen between serum C peptide, and urine albumin,urine albumin creatinine ratio, HbA1C and duration of diabetes. Mean urine albumin was higher in patients with subnormal Cpeptide level. Duration of disease was more in patients with lower serum C peptide level. The study has shown weak associationof serum C peptide level with microalbuminuria and creatinine clearance. Risk of albuminuria is more in patients with low serumC peptide level. .

Item Type: Article
Uncontrolled Keywords: C peptide, creatinine clearance, microalbuminuria
Subjects: Medicine > KMC Mangalore > Ophthalmology
Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 23 Sep 2011 06:19
Last Modified: 18 Oct 2011 06:06
URI: http://eprints.manipal.edu/id/eprint/1373

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