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Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies

Khan, Saleemulla (2009) Hepatoprotective evaluation of Anogeissus latifolia: In vitro and in vivo studies. World Journal of Gastroenterology, 15 (38). pp. 4816-4822. ISSN 1007-9327

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Abstract

AIM:To evaluate the hepatoprotective activity of a hy - droalcoholic extract of the bark of Anogeissus latifolia ; in vitro in primary rat hepatocyte monolayer culture and in vivo in the liver of Wistar rats intoxicated by carbon tetrachloride (CCl 4 ). METHODS: In the in vitro study, a primary hepatocyte monolayer culture was treated with CCl 4 and extract of Anogeissus latifolia. Hepatoprotective activity was demonstrated in the CCl 4 damaged primary monolayer culture. In the in vivo study, the hepatoprotective activ - ity of a hydroalcoholic extract of Anogeissus latifolia was analyzed in liver injured CCl 4 -treated rats. Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. The biochemical findings were supplemented with histopathological examination of rat liver sections. RESULTS: In vitro: primary hepatocyte monolayer cul-tures were treated with CCl 4 and extract of Anogeissus latifolia . A protective activity could be demonstrated in the CCl 4 damaged primary monolayer culture. In vivo : Hydroalcoholic extract of Anogeissus latifolia (300 mg/kg) was found to have protective activity in rats with CCl 4 -induced liver damage as judged from se - rum marker enzyme activity. CONCLUSION: The above findings lead to the con -clusion that the hydroalcoholic extract of Anogeissus latifolia is hepatoprotective. Hence, we suggest that the inclusion of this plant in the management of liver disorders is justified.

Item Type: Article
Uncontrolled Keywords: Anogeissus latifolial; Hepatoprotective; Carbon tetrachloride
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 01 Oct 2013 11:27
Last Modified: 01 Oct 2013 11:27
URI: http://eprints.manipal.edu/id/eprint/137372

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