Expression of Mismatch Repair Protein Mlh1 in Primary Oral Squamous Cell Carcinoma in An Indian Population – An Immunohistochemical Study

Singh, Ankur and Solomon, Monica Charlotte and Raghu, AR and Guddattu, Vasudeva and Singh, Gurshinder Pal (2013) Expression of Mismatch Repair Protein Mlh1 in Primary Oral Squamous Cell Carcinoma in An Indian Population – An Immunohistochemical Study. Indian Journal of Applied Research, 3 (10). pp. 1-6. ISSN 2249-555X

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Abstract

Background: MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), also known as MLH1 is an integral DNA mismatch repair (MMR) gene whose role in tumorigenesis has been implicated in an extensive group of human cancers. Our study attempted to correlate MLH1 immunoexpression with different clinicopathological parameters in oral squamous cell carcinoma (OSCC) by immunohistochemical staining. Materials and method: A retrospective cross-sectional study was carried out to detect MLH1 in formalin fixed paraffin embedded (FFPE) specimens of OSCC (n=60) by immunohistochemistry. Results: Positive nuclear expression of MLH1 in tumor cells was recorded and scored. An over expressed MLH1 in well differentiated OSCC cases with a significant reduction in its expression with deteriorating histologic grade was observed (P<0.001). Also, the MLH1 immunoexpression was directly proportional to the tumor stage (P<0.05). Conclusion: The over expression of MLH1 thus reflects an attempt to amend the DNA lesions through the MMR system and restore genomic stability. Analysis of MLH1 expression may assist in prognostication and aid in designing superior treatment protocols.

Item Type: Article
Uncontrolled Keywords: DNA mismatch repair; carcinoma; squamous cell; immunohistochemistry.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Departments at MU > Statistics
Medicine > KMC Manipal > ENT
Depositing User: KMC Manipal
Date Deposited: 05 Oct 2013 04:18
Last Modified: 21 Jun 2014 06:48
URI: http://eprints.manipal.edu/id/eprint/137412

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