Chandrappa, C P and Govindappa, M and Kumar, Anil N V (2013) In vitro antimitotic, antiproliferative and DNA fragmentation assay of ethanol extract of Carmona retusa (Vahl.) Masam. Applied Cell Biology, 2 (2). pp. 52-57. ISSN 2320–1991

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Abstract

Carmona retusa leaf decoction is being used to treat cough and stomach ache root as antidote. This plant is also reported antibacterial, anti-inflam- matory, anti-analgesic and antidiabetic activity. Hence, our present study was performed to evaluate in vitro cytotoxicity, antiproliferative, antimi- totic and DNA fragmentation assays. Fresh stem of Carmona retusa was collected from Hemagangothri Campus, Hassan district of Karnataka, In- dia. Flask extraction procedure was adapted for extraction with alcohol. Alcohol extract was subjected to in vitro anti-mitotic, anti-proliferative activity and DNA fragmentation assay. The alcoholic extract of C. retusa has shown significant antimitotic and antiproliferative activity. The mi- totic index was found to be 12.5 and 12.7 mg/mL respectively, which was near to standard, lapachol 12.2. Based on the results obtained, it is con- cluded that Carmona retusa may be the good candidate for the treatment of cancer as plant extracts have shown anti-mitotic and anti-proliferative activity A. cepa and yeast respectively.

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