Comparative Study of Anti - Emetic Efficacy of Palonosetron with Ondansetron And Metoclopramide

Rao, Sumesh T and Upadya, Madhusudan and *, Karthik Narendrakumar and *, Deepa Thiagarajan (2013) Comparative Study of Anti - Emetic Efficacy of Palonosetron with Ondansetron And Metoclopramide. Indian Journal of Applied Research, 3 (10). pp. 1-3. ISSN 2249 - 555X

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Abstract

Aim: This study was designed to assess the safety and efficacy of palonosetron in comparison with ondansetron and metoclopramide administered intravenously before general anesthesia for prevention of post operative nausea and vomiting. Patients and methods: A randomized prospective study was carried out in 60 patients aged 18-65 yrs of ASA grade I, II and III. They were categorized into 3 groups. Group P (n = 20) received Inj: palonosetron 0.25mg, Group O (n = 20) Inj: ondansetron 4 mg and Group M (n = 29) Inj: metoclopramide 10 mg. Results: Statistically, no significant difference was found in the anti-nausea efficacy of palonosetron compared to ondansetron and metoclopramide. Comparing overall incidence of vomiting showed that the antiemetic efficacy of palonosetron is the same as ondansetron and metoclopramide for post-operative emesis.

Item Type: Article
Uncontrolled Keywords: Palonosetron, PONV, antiemetics
Subjects: Medicine > KMC Mangalore > Anaesthesiology
Depositing User: KMCMLR User
Date Deposited: 11 Oct 2013 10:42
Last Modified: 11 Oct 2013 10:42
URI: http://eprints.manipal.edu/id/eprint/137441

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