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Crotalaria pallida extracts as a putative HIV-protease inhibitors

Govindappa, M and Kumar, Anil N V and Santoyo, Gustavo Crotalaria pallida extracts as a putative HIV-protease inhibitors. Journal of Research in Biology, 1 (4). pp. 285-291.

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Abstract

In the present investigation, we screened the two solvent (methanol and ethanol) extracts of Crotalaria pallida different parts (leaf, flower and stem) for phytochemical analysis and screening for HIV protease inhibitors. The two solvent extracts have yielded the presence of major active compounds viz., flavonoids, terpenoids, cardiac glycosides, anthraquinones, coumarins, steroids, tannins, saponins. For HIV protease inhibitor activity, we used pepsin assay as a substitute for screening HIV protease inhibitors in the present investigation. The methanol and ethanol extracts of stem and flower have showed significant inhibition of protease activity as compared to standard (Pepstatin A).

Item Type: Article
Uncontrolled Keywords: Phytochemicals, Crotalaria pallida, HIV protease.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 10 Oct 2013 10:25
Last Modified: 10 Oct 2013 10:25
URI: http://eprints.manipal.edu/id/eprint/137442

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