*, Surendran Sudarshan and Nayak, Satheesha B and Madhyastha, Sampath (2013) Effect of unilateral intracerebrovascular injection of kainic acid on the dendritic intersection of CA3 neurons of hippocampus at the end of 04 weeks. International Journal of Pharmacy and Biological Sciences, 3 (2). pp. 86-94. ISSN 2230-7605

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Abstract

Temporal lobe epilepsy (TLE) ,a chronic brain disorder characterized by recurrent seizures with temporal lobe origin is the frequent type of epilepsy in humans. Mesial temporal sclerosis is seen in TLE ,in addition to complex partial seziures that might that might spread to cause convulsive seizures. Kainite model of TLE is a well known model known to mimic hippocampal sclerosis ,as seen in patients with temporal lobe epilepsy. In this study kainic acid was injected into the right lateral ventricle of 04 months old wistar rats to create the model of TLE. At the end of 04 weeks posstintracerebrovscular injection of kainicacid,the changes in the number of dendritic intersections were quantified,both in apical and basal dendrites,for understanding of dendritic modifications in TLE. There was a significant decrease seen in apical dendrites on the ipsilateral side and the basal dendritic intersections showed a decrease both on ipsilateral and contralateral sides.Experimental procedures and results have been discussed .

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