Resveratrol improves postnatal hippocampal neurogenesis and brainderived neurotrophic factor in prenatally sressed rats

Madhyastha, Sampath and *, Sudhanshu Sekhar Sahu and Rao, Gayathri (2013) Resveratrol improves postnatal hippocampal neurogenesis and brainderived neurotrophic factor in prenatally sressed rats. International Journal of Developmental Neuroscience, 31. pp. 580-585.

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Abstract

tPrenatal stress induced neuronal dysfunction is multifactorial, including suppressed neurogenesis indeveloping brain. Resveratrol is known to exert its neuroprotective potential by enhancing neurogene-sis. But the efficacy of resveratrol against prenatal stress was not addressed in detail. Hence in the presentstudy we evaluated the neuroprotective action of resveratrol on prenatal stress-induced impaired neuro-genesis. Pregnant rats were subjected to restraint stress during early or late gestational period. Anothersets of rats received resveratrol during entire gestational period along with early or late gestationalstress. The study parameters included neuronal assay of doublecortin positive neurons (DCX +ve) andbrain derived neurotrophic factor (BDNF) estimations in 40th postnatal day rat brain. Both early and lategestational stress resulted in significant decrease in generation of new born neurons and BDNF expres-sion in hippocampus. The decrease in number of DCX +ve neurons and hippocampal BDNF expressionwas more profound in the offspring who received late gestational stress compared to early gestationalstress. Resveratrol treatment has improved the expression of DCX +ve neurons and BDNF expression.These data suggest the neuroprotective efficacy of resveratrol against prenatal stress induced impairedneurogenesis.

Item Type: Article
Uncontrolled Keywords: Prenatal stress , resveratrol, neurogenesis, doublecortin, BDNF, Hippocampus
Subjects: Medicine > KMC Mangalore > Anatomy
Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 11 Oct 2013 10:43
Last Modified: 11 Oct 2013 10:43
URI: http://eprints.manipal.edu/id/eprint/137465

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