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Mifepristone in the induction of labour at term

*, Shanitha Fathima and Nayak, S.R. and Rao, Bharathi and *, Gandhi Praveena and *, Shameem V.P.A (2013) Mifepristone in the induction of labour at term. International Journal of Pharmaceutical and Biomedical Research, 4 (3). pp. 164-166. ISSN 0976-0350

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Abstract

Objectives: To assess the ability of mifepristone to prime the cervix and induce labor at term. When mifepristone alone is insufficient, to determine if vaginal misoprostol used sequentially, is effective in inducing labor. Methods: Hospital based, prospective randomized comparative study conducted in Lady Goschen Hospital and Kasturba Medical College, Mangalore. Inclusion criteria were women with singleton pregnancy (confirmed by USG) with gestational age 37-42 weeks and cervical Bishop’s score<6. Exclusion criteria were parity>5, scarred uterus, hypersensitivity to prostaglandins or mifepristone, major cephalopelvic disproportion, impaired renal hepatic or adrenal function, antepartum haemorrage and severe oligohydramnios. Statistical analysis was performed using the χ2 test and p<0.05 was considered significant. Results: The study demonstrated significant efficacy of mifepristone for cervical ripening and induction of spontaneous labor after drug administration as more women had favorable Bishop’s scores at the end of 48h. In the present study 66% of women entered labor spontaneously or had a sufficiently ripened cervix within 48h of intake of mifepristone, but there was no difference in time between prostaglandin administration and delivery interval between the groups. There were less no. of caesarean section in the study group but the difference was not statistically significant. Maternal complications and neonatal out comes were comparable in both the group. Even though, there is a theoretical risk of hypoglycemia in the newborn, the present study showed no difference in the same among the 2 groups. Conclusion: Mifepristone (RU 486) is a safe, efficient and suitable agent for cervical ripening and for initiation of labor when given 48h before labor induction.

Item Type: Article
Uncontrolled Keywords: Dinaprostone, Induction, Mifepristone, Term
Subjects: Medicine > KMC Mangalore > Obstetrics & Gynaecology
Depositing User: KMCMLR User
Date Deposited: 14 Oct 2013 06:03
Last Modified: 14 Oct 2013 06:03
URI: http://eprints.manipal.edu/id/eprint/137473

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