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Mifepristone plus misoprostol versus only-misoprostol in induction of labour in intra uterine fetal death

*, Gandhi Praveena and *, Shameem V.P.A and Rao, Arun A. and Rao, Bharathi (2013) Mifepristone plus misoprostol versus only-misoprostol in induction of labour in intra uterine fetal death. International Journal of Pharmaceutical and Biomedical Research, 4 (2). pp. 108-110. ISSN 0976-0350

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Abstract

Objectives: To compare the efficacy and safety of mifepristone plus misoprostol versus only-misoprostol in the induction of labour in the case of Intra Uterine Fetal Death (IUFD). Methods: Data from 62 women with IUFD (20-42 weeks POG) were analysed retrospectively. A total of 28 women comprise group A, received 200mg of mifepristone given per oral. 48h later 50/200μg misoprostol administered in the posterior vaginal fornix and repeated 6th hourly maximum of four doses. A total of 34 women comprise group B, received only 50/200μg misoprostol administered in the posterior vaginal fornix and repeated 6th hourly maximum of four doses. If not expelled after four doses of misoprostol, gap of 24h from the first dose was given and the course of four dose of misprostol repeated. Statistical analysis was performed using the Mann-Whitney U-test, the χ2 test, Kruskal-Wallis test and Fisher’s exact t test as appropriate. A p-value of <0.05 was considered significant. Results: Number of misoprostol doses used in each subgroup was not statistically significant. Mean dose was less in group A with a value of 1.75 and p value is 0.257. Mean IDI was 10.55 and 12.555h in group A and B respectively and p value is 0.227. Conclusion: The combination of mifepristone and misoprostol for induction of labour, in intermediate and late IUFD, has shorter induction to delivery interval and lesser number of misoprostol doses usage; when compared to misoprostol only group. Further studies are required in establishing an effective management of IUFD.

Item Type: Article
Uncontrolled Keywords: Induction, Intra Uterine Fetal Death, Mifepristone, Misoprostol
Subjects: Medicine > KMC Mangalore > Obstetrics & Gynaecology
Depositing User: KMCMLR User
Date Deposited: 14 Oct 2013 06:03
Last Modified: 14 Oct 2013 06:03
URI: http://eprints.manipal.edu/id/eprint/137475

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