Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation

Makhija, Inder K and Shreedhara, Chandrashekara S and Ram, Aswatha HN (2013) Mast cell stabilization potential of Sitopaladi churna: An ayurvedic formulation. Pharmacognosy Research, 5 (4). pp. 306-308.

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Background: Sitopaladi churna (SPC) is a popular polyherbal ayurvedic formulation used in the treatment of allergy and respiratory diseases. Objective: The present study was aimed to justify the classical use of antiallergic claim by performing the mast cell stabilizing activity of extracts of SPC. Materials and Methods: The protective effect of aqueous extract and methanolic extract - of SPC against compound 48/80-induced mast cell degranulation model was carried out. Results: Sitopaladi churna aqueous extract (SPCA) at the dose of 300 mg/kg and Sitopaladi churna methanolic extract (SPCM) at the doses of 150 and 300 mg/kg showed better protection of mast cell degranulation (65%-74%) and were comparable to the standard drug ketotifen (79%), when peritoneal mast cells were treated with compound 48/80. The protection against mast cell degranulation was significant (P < 0.0001). Conclusion: From the above results, it has been justified that SPC can be used to treat allergic disorders.

Item Type: Article
Uncontrolled Keywords: Compound 48/80; mast cell stabilizing; Sitopaladi churna.
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 18 Oct 2013 11:10
Last Modified: 18 Oct 2013 11:10

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