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Synthesis and biological evaluation of 2,4-disubstituted-[1,3]-thiazoles

*, Sumangala V. and Poojary, Boja and *, Chidananda N. and *, Arulmoli T. and Shenoy, Shalini (2012) Synthesis and biological evaluation of 2,4-disubstituted-[1,3]-thiazoles. Journal of Chemical and Pharmaceutical Research, 4 (12). pp. 4979-4987.

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Abstract

In the present study a series of novel 2,4-disubstituted-[1,3]-thiazole derivatives were synthesized by the reaction of 2-chloro-6-fluoro/2-fluorobenzaldehyde thiosemicarbazone with phenacyl bromide. 2-chloro-6-fluoro/2- fluorobenzaldehyde thiosemicarbazone was obtained by treating aldehyde thiosemicarbazone with thiosemicarbazide in the presence acetic acid in ethanol under reflux. Structures of newly synthesized compounds were characterized by spectral studies. New compounds were screened for their antimicrobial study and cytotoxic study. The results revealed that many of the synthesized thiazoles have good cytotoxicity and antimicrobial activity.

Item Type: Article
Uncontrolled Keywords: [1,3]-Thiazoles, cytotoxicity, antimicrobial activity.
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 24 Oct 2013 06:43
Last Modified: 24 Oct 2013 06:43
URI: http://eprints.manipal.edu/id/eprint/137548

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