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Synthesis, characterization and antimicrobial activity of some 2,5-disubstituted-3-acetyl-[1,3,4]-oxadiazoles carrying 2-(aryloxymethyl) phenyl moiety

*, Naveena C.S and Poojary, Boja and Kumsi, Manjunath and Thangavel, Arulmoli and Shenoy, Shalini (2011) Synthesis, characterization and antimicrobial activity of some 2,5-disubstituted-3-acetyl-[1,3,4]-oxadiazoles carrying 2-(aryloxymethyl) phenyl moiety. Der Pharma Chemica, 3 (6). pp. 247-257. ISSN 0975-413X

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Abstract

A series of 3-acetyl-2-aryl-5-[2-(aryloxymethyl)phenyl]-2,3-dihydro-[1,3,4]-oxadiazoles (4a-p) have been synthesized and evaluated for their antimicrobial activity. Initially, the acid hydrazides (2a-d) derived from 2-(aryloxymethyl) benzoic acids (1a-d) were reacted with various aromatic aldehydes to yield hydrazones (3a-p). Further reaction of these hydrazones with acetic anhydride afforded the title compounds. All structures of the new compounds were established on the basis of their elemental analyses, IR, 1H NMR, 13C NMR and mass spectral data. The newly synthesized compounds were evaluated for their antimicrobial activities. Preliminary results indicated that some of them exhibit promising activities and they deserve more consideration as potential antimicrobial agents.

Item Type: Article
Uncontrolled Keywords: 1,3,4-Oxadaiazoles; Antibacterial activity; Antifungal activity; 2-(Aryloxymethyl) phenyl moiety; dehydrative cyclization.
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 24 Oct 2013 06:44
Last Modified: 24 Oct 2013 06:44
URI: http://eprints.manipal.edu/id/eprint/137556

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