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Synthesis, characterization, antimicrobial and antioxidant activity of some disubstituted [1,3,4]-oxadiazoles carrying 4-(methylsulfonyl/sulfinyl)benzyl moieties

*, Sumangala V. and Poojary, Boja and *, Chidananda N. and *, Arulmoli T. and Shenoy, Shalini (2012) Synthesis, characterization, antimicrobial and antioxidant activity of some disubstituted [1,3,4]-oxadiazoles carrying 4-(methylsulfonyl/sulfinyl)benzyl moieties. Journal of Chemical and Pharmaceutical Research, 4 (3). pp. 1661-1669. ISSN 0975-7384

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Abstract

Disubstituted [1,3,4]-oxadaiazoles (6a-b), Mannich bases (7a-f) and S-alkylated derivatives (8a-f) have been synthesized from 4-(methylsulfonyl/sulfinyl)phenylaceticacid (3a-b) through a multi-step reaction sequence starting from (4-methylthio)phenylacetonitrile (1). The structures of new compounds were established on the basis of their elemental analysis, IR, 1H NMR, 13C NMR and mass spectral data. All the synthesized compounds were screened for their antioxidant, antibacterial and antifungal activity. Some of the derivatives have promising antimicrobial activity.

Item Type: Article
Uncontrolled Keywords: [1,3,4]-Oxadaiazoles; antioxidant; antimicrobial activity; [1,3,4]-Oxadiazol-2-thiones; 4-(methyl sulfonyl/sulfinyl)benzyl moiety.
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 24 Oct 2013 06:44
Last Modified: 24 Oct 2013 06:44
URI: http://eprints.manipal.edu/id/eprint/137558

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