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Synthesis and antibacterial activities of some fluorine containing arylfurylpropenones, pyrazolines and N- acetylpyrazoline

Holla, ShivaramaB and *, Shivananda, M K and *, Akberali, P M and Shenoy, Shalini (2000) Synthesis and antibacterial activities of some fluorine containing arylfurylpropenones, pyrazolines and N- acetylpyrazoline. Indian Journal of Chemistry , 39(B) (06). pp. 440-447. ISSN 0376-4699

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Abstract

Several fluorine containing arylfurylpropenones 3 have been synthesized starting from arylfurfurals 1 and 2,4-dichloro-5- fluoroacetophenone 2. These arylfurylpropenones are then used for the synthesis of fluorine containing arylfurylpyrazolines 4.The newly synthesized pyrazolines are then converted into their N-acetyl derivatives 5. The structures of these compounds have been confirmed on the basis of elemental analysis, IR, NMR and mass spectral studies. The mechanism for the formation of pyrazolines has been investigated. The above compounds are also subjected to antibacterial screening. Their minimal inhibitory concentration (MIC) values indicate that some of these compounds exhibit excellent antibacterial activities.

Item Type: Article
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 24 Oct 2013 06:44
Last Modified: 24 Oct 2013 06:44
URI: http://eprints.manipal.edu/id/eprint/137564

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