In-vitro anti-diabetic evaluation of terminalia tomentosa (Roxb). bark

Sharma, Meenakshi and Lobo, Richard and Setty, Manjunath M and Khan, Saleemulla and Chandrashekhar, KS and Sreedhara, CS (2013) In-vitro anti-diabetic evaluation of terminalia tomentosa (Roxb). bark. World Journal of Pharmaceutical Research, 2 (6). pp. 2366-2372. ISSN 2277 – 7105

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Abstract

Diabetes mellitus is a disease caused by the imbalenced carbohydrate, fat and protein metabolism, caused due to either lack of insulin secretion or decreased sensitivity of the tissues to insulin, and is characterized by chronic raise in blood sugar levels termed as hyperglycaemia. The present work demonstrate the in vitro antidiabetic activity of Ethanolic and Aqueous extract of Terminalia tomentosa stem bark. The extracts were studied for their effect on inhibition of glycosylation of haemoglobin, and α-Amylase inhibition. Inhibition of glycosylation of haemoglobin and α- Amylase inhibition was found to be in a dose dependent manner. The results obtain confirms Terminalia tomentosa bark possesses antidiabetic activity. However, further studies on the extract and isolated constituents to be carried out on in vivo models and clinical trials for its effective utilization as therapeutic agents.

Item Type: Article
Uncontrolled Keywords: Terminalia tomentosa; antidiabetic; Acarbose; glycosylation.
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 18 Nov 2013 04:11
Last Modified: 18 Nov 2013 04:11
URI: http://eprints.manipal.edu/id/eprint/137708

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