A Prospective Cohort Study of Cryptococcal Meningitis in Hiv Patients in a Tertiary Care Hospital

Shenoy, Suchitra M and Singh , Smitha and Paul , Diana and Baliga, Shrikala (2013) A Prospective Cohort Study of Cryptococcal Meningitis in Hiv Patients in a Tertiary Care Hospital. Indian Journal of Applied Research, 3 (8). pp. 25-26. ISSN 2249 - 555X

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Abstract

Cryptococcal meningitis is an AIDS defining illness caused by an encapsulated fungal organism that has more predilections for the immune compromised. This hospital based prospective cohort study was done to analyze clinical and microbiological features of cryptococcal meningitis in patients with acquired immunodeficiency syndrome (AIDS). The study included demography, clinical presentation, CD4 counts, CSF analysis, microbiological diagnosis, biotype of the Cryptococcus, and the antifungal susceptibility testing of the isolates. 28 cases of Cryptococcal meningitis were confirmed during the three year study period. The CD4 count ranged from 60 to 198 cells /μl. All 28 patients were positive for culture, 71.4% were positive for India ink preparation and 89.2% were positive for Latex agglutination test. All the isolates were sensitive to Amphotericin B, Itraconazole and Voriconazole, and eight were resistant to Fluconazole. Combining all three tests can increase chances of early detection and help the clinician to initiate early antifungal therapy.

Item Type: Article
Uncontrolled Keywords: Cryptococcal meningitis, antifungal resistance, fluconazole
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 20 Nov 2013 05:28
Last Modified: 20 Nov 2013 05:28
URI: http://eprints.manipal.edu/id/eprint/137750

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