Impact of caffeic acid on aluminium chloride-induced dementia in rats

Khan, Kafeel A and Kumar, Nitesh and Nayak, Pawan G and Nampoothiri, Madhavan and Shenoy, Rekha R and Nandakumar, Krishnadas and Rao, Mallikarjuna C and Mudgal, Jayesh (2013) Impact of caffeic acid on aluminium chloride-induced dementia in rats. Journal of Pharmacy and Pharmacology, 65. pp. 1745-1752.

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Abstract

Objective Literature favours the in vitro neuroprotective role of caffeic acid, a naturally derived polyphenolic compound. This study was aimed to investigate the role of caffeic acid in experimental model of Alzheimer’s disease. Methods Firstly, caffeic acid was tested for in vitro anticholinesterase potential using rat brain homogenate. Later, in vivo antidementia activity of caffeic acid was assessed against aluminium chloride (AlCl 3 )-induced dementia in rats. Behavioural (Morris water maze test) and brain biochemical parameters (acetylcholinesterase (AChE), catalase, glutathione-S-transferase (GST) activity, glutathione (GSH) and nitrite levels) were assessed to correlate the cognitive func- tion with cholinergic transmission and oxidative stress. Key findings Rats administered with caffeic acid showed improved cognitive function in Morris water maze test. The antidementia activity of caffeic acid was confirmed by the reduction in brain AChE activity and nitrite levels. Further, caffeic acid corrected the diminished level of antioxidant enzymes such as catalase, GSH and GST in brain. Conclusion These findings suggest the antidementia activity of caffeic acid against AlCl 3 -induced dementia in rats. The outcome of present study offers a wider scope to screen caffeic acid against neurodegeneration associated disorders.

Item Type: Article
Uncontrolled Keywords: Acetylcholinesterase; Aluminium chloride; Caffeic acid; Morris water maze; Oxidative stress
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 21 Nov 2013 04:25
Last Modified: 21 Nov 2013 04:25
URI: http://eprints.manipal.edu/id/eprint/137757

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