Significance of Salivary Phosphodiesterase Level in Oral Squamous Cell Carcinoma Patients

Chianeh, Yousef Rezaei and Prabhu, Krishnananda and Rashmi, M and Fernandes, Donald J (2013) Significance of Salivary Phosphodiesterase Level in Oral Squamous Cell Carcinoma Patients. International J ournal of Research in Medical Sciences, 1 (4). pp. 417-420. ISSN 2320 - 6012

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Abstract

Oral cancer, more specifically oral squamous cell carcinoma (OSCC) consider as common cancer that 300,000 people diagnosed per year worldwide .The only effective treatment for OSCC is surgical intervention. Over the past two decades, overall disease condition has not improved although advancement of treatment has considerably increased .The phosphodiesterase (PDEs) are responsible for the hydrolysis of the second messengers with a fundamental role in the transduction of the in tracellular signals. In numerous pathological conditions such as cellular differentiation, apoptosis, and tumor invasivity the different PDF activity has been observed that shown role in pathophysiological mechanism. The role of PDEs as an intervention factor for activation of angiogenesis by influencing a tumor growth has been shown. The objective of this study was to estimate and compare salivary PDEs levels in healthy controls and biopsy - proven oral cancer patients before definitive therapy. Study was do ne in patients age between 25 -65 years biopsy proven oral cancer patients and control group. After obtaining prior consent from biopsy - proven oral cancer patients (n=26) (before onset of any definitive treatment) and age - and sex - matched healthy controls ( n=29), salivary sample was collected for estimation of the activity of phosphodiesterases (PDEs).

Item Type: Article
Uncontrolled Keywords: Oral cancer; Oral squamous cell carcinoma (OSCC); Phosphodiesterases (PDEs)
Subjects: Medicine > KMC Manipal > Biochemistry
Medicine > KMC Manipal > Radiotherapy and Oncology
Depositing User: KMC Manipal
Date Deposited: 22 Nov 2013 04:15
Last Modified: 22 Nov 2013 04:15
URI: http://eprints.manipal.edu/id/eprint/137777

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