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Unlocking the mystery of paracetamol mechanism of action and existance of cox-3-A review

*, Shivaprakash G and Rao, Jagadish Padubidri and *, Pallavi LC (2013) Unlocking the mystery of paracetamol mechanism of action and existance of cox-3-A review. International Journal of Universal Pharmacy and Bio Sciences, 2 (6). pp. 317-324. ISSN 2319-8141

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Abstract

Paracetamol is a commonly used NSAID (Non-steroidal anti-inflammatory agent) since its introduction by Von Mering in 1893. Its popularity is because of its long safety record and good efficacy in children and adults. Though it has been used for so many years, its mechanism of action is yet to be elucidated. NSAIDS inhibit prostaglandin synthesis by inhibiting COX-1(Cyclooxygenase-1) and COX-2(Cyclooxygenase 2) enzymes and produce analgesic, antipyretic and anti-inflammatory activity. Paracetamol like other NSAIDS produce analgesic and antipyretic effects, but is a poor anti-inflammatory agent which suggests a different mechanism of action. COX-3 a novel isoform was discovered to unravel the mystery surrounding paracetamol mechanism of action. Similarly, multiple mechanism of actions rooted in an effort to explain this differential pharmacological actions. This review is an effort to unravel this mystery by critically analyzing the available literature on paracetamol mechanism of action.

Item Type: Article
Uncontrolled Keywords: Paracetamol; NSAIDS; COX-3.
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Forensic Medicine
Depositing User: KMCMLR User
Date Deposited: 27 Nov 2013 05:27
Last Modified: 27 Nov 2013 05:27
URI: http://eprints.manipal.edu/id/eprint/137827

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