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Correlation of Severity of Coronary Artery Disease with Insulin Resistance

*, Mukund P Srinivasan and Kamath, Padmanabh K and Manjrekar, Poornima and *, Unnikrishnan B and Ullal, Aishwarya and Kotekar, Mohammed Faheem and *, Chakrapani M (2013) Correlation of Severity of Coronary Artery Disease with Insulin Resistance. North American Journal of Medical Sciences, 5 (10). pp. 611-614.

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Abstract

Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross‑sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein‑cholesterol ratio were determined. Homeostasis model assessment‑IR (HOMA‑IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA‑IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.

Item Type: Article
Uncontrolled Keywords: Coronary artery disease, Insulin resistance, Type 2 diabetes mellitus
Subjects: Medicine > KMC Mangalore > Biochemistry
Medicine > KMC Mangalore > Community Medicine
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 28 Nov 2013 06:30
Last Modified: 28 Nov 2013 06:30
URI: http://eprints.manipal.edu/id/eprint/137845

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