Effect of Lipodystrophy on Quality of life of HIV/AIDS patients: A cross sectional study in South India

Dhar, Murali (2013) Effect of Lipodystrophy on Quality of life of HIV/AIDS patients: A cross sectional study in South India. International Journal of Recent Trends in Science A nd Technology, 9 (1). pp. 20-23. ISSN 2249-8109

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Background: Introduction of ART has initially improved the quality of life (QoL) of HIV positive patients, however body fat redistribution and metabolic disorders associated with long-term ART use may attenuate this improvement. As access to treatment improves in India, the disfiguring nature of lipodystrophy (peripheral atrophy and/or central adiposity) may deter treatment adherence and decrease QoL. Objective: To study the relation between lipodystrophy and QoL in ART-treated HIV+ p atients. Methodology: The study was conducted in January 2012 to August 2012. This cross sectional study was done in 1000 H IV/AIDS patients out of which 255 had lipodystrophy at ART centre K.R Hospital, Mysore. WHO-QOL-Brief a summarized quality of life questionnaire was used to assess the Quality of life. Physical examination was done to assess lipodystrophy. Statistical analysis was done using SYSTAT 13 software. To test the significance, t test was applied. Results: Out of 255 patients, who had lipodystrophy, 163 of them were male and 92 of them were females. Facial atrophy was more common among males and abdominal enlargement was found more commonly associated with females. The Quality of life score was found significantly less among HIV patients with lipodystrophy than those without. However CD4 count was found to be significantly higher in patients with lipodystrophy than those without.Conclusion: Body fat alterations negatively affect quality of life. These symptoms may result in stigmatization and marginalization and adversely affect ART adherence and treatment initiatives. Efforts to evaluate self-perceived body fat changes may improve patient ’s wellbeing, ART adherence and treatment outcomes can contribute towards stability in quality of life continuum.

Item Type: Article
Uncontrolled Keywords: HIV; ART; Quality of Life; Lipodystrophy and CD4
Subjects: Departments at MU > Statistics
Depositing User: KMC Manipal
Date Deposited: 02 Dec 2013 04:13
Last Modified: 02 Dec 2013 04:13
URI: http://eprints.manipal.edu/id/eprint/137870

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