Fusidic acid-topical antimicrobial in the management of staphylococcus aureus

Musmade, Prashant B and Tumkur, Anil and Trilok, M and Bairy, KL (2013) Fusidic acid-topical antimicrobial in the management of staphylococcus aureus. International Journal of Pharmacy and Pharmaceutical Sciences, 5 (4). pp. 381-390. ISSN 0975-1491

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Abstract

Fusidic acid (FA) is derived from the fungus Fusidiumcoccineum which was originally isolated from monkey faeces and available in the market since 1962. FA inhibits bacterial protein synthesis by interference with elongation factor G (EF-G), which promotes translocation on the ribosome after peptide bond formation, preventing further elongation by inhibiting the GTPase function of the EF-G. The steroid like structure of FA confers good skin penetration and does not possess the unwanted side effects of steroids.

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Quality Assurance
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 02 Dec 2013 04:15
Last Modified: 02 Dec 2013 04:15
URI: http://eprints.manipal.edu/id/eprint/137871

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